Peripheral myelin protein 22 is regulated post-transcriptionally by miRNA-29a

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Peripheral myelin protein 22 alters membrane architecture

Peripheral myelin protein 22 (PMP22) is highly expressed in myelinating Schwann cells of the peripheral nervous system. PMP22 genetic alterations cause the most common forms of Charcot-Marie-Tooth disease (CMTD), which is characterized by severe dysmyelination in the peripheral nerves. However, the functions of PMP22 in Schwann cell membranes remain unclear. We demonstrate that reconstitution o...

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ژورنال

عنوان ژورنال: Glia

سال: 2009

ISSN: 0894-1491,1098-1136

DOI: 10.1002/glia.20846